This is done using KOH and EtOH for hydrolysis, and then adding SOCl 2 for chlorination to form the acid chloride which reacts with the addition of lithium anion. Compound 1 is transformed into Compound 2 by consecutive hydrolysis, halogenation to form an acid chloride, and then reacted with the required lithium anion. To obtain this starting Compound 1, a simple Wittig condensation of ethyl chloroacetate with 4’-bromobiphenylcarboxaldehyde is accomplished. Compound 1 is the starting ester needed to synthesize brodifacoum. Compounds numbers are found next to their respective compounds in the image below. In March 2018, cases of severe coagulopathy and bleeding associated with synthetic cannabinoid use contaminated with brodifacoum were reported in five states of the US.īrodifacoum is a derivative of the 4-hydroxy-coumarin group. Significant experience in brodifacoum poisonings has been gained in many human cases where it has been used in attempted suicides, necessitating long periods of vitamin K treatment. It has one of the highest risks of secondary poisoning to both mammals and birds.

īrodifacoum has an especially long half-life in the body, which ranges up to nine months, requiring prolonged treatment with antidotal vitamin K for both human and pet poisonings. It is typically used as a rodenticide, but is also used to control larger pests such as possums. In recent years, it has become one of the world's most widely used pesticides. Brodifacoum is a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison.

Mouse poison with vitamin k antidote